The Research Triangle region of North Carolina is home to world-class research institutions, including Duke University, the University of North Carolina at Chapel Hill, and North Carolina State University. The region is known for its cutting-edge research in fields such as biotechnology, pharmaceuticals, and information technology.

The TriPoD was formed in 2023 out of a shared interest and recognition that the protein engineering field is currently undergoing a revolution driven by deep-learning, biophysics, directed evolution, and other approaches. Members of the TriPoD have the opportunity to collaborate, share knowledge, and stay up-to-date with the latest advancements in the field. The club aims to facilitate discussions on protein design challenges and foster a supportive community to tackle them together.